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Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

BAM is also associated with diarrhea, caused by an increase in colonic BA concentrations due to BA insufficient recycling or overproduction (Sadik et al., 2004

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Computational models of complex Ca 2+ dynamics incorporating store-operated Ca 2+ entry and MAM geometry further underscore the nonlinear behavior of this system and its sensitivity to small changes in channel density, ER store content, or mitochondrial buffering capacity ( 2+ transfer and mitochondrial Ca 2+ overload are early pathogenic events, whereas oxidative stress, inflammatory activation, and impaired clearance of damaged mitochondria contribute mainly to propagation and amplification of acinar cell injury